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Nutlin-3, the small-molecule inhibitor of MDM2, promotes senescence and radiosensitises laryngeal carcinoma cells harbouring wild-type p53.

Abstract:

BACKGROUND: Primary radiotherapy (RT) is a mainstay of treatment for laryngeal squamous cell carcinoma (LSCC). Although the cure rates for early (T1) vocal cord tumours are high, RT proves ineffective in up to a third of T3 carcinomas. Moreover, RT is associated with debilitating early- and late-treatment-related toxicity, thus finding means to de-escalate therapy, while retaining/augmenting therapeutic effectiveness, is highly desirable. p53 is a key mediator of radiation responses; we ther...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6605739

Authors


El-Fert, A More by this author
Devling, T More by this author
Eccles, RM More by this author
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Journal:
British journal of cancer
Volume:
103
Issue:
2
Pages:
186-195
Publication date:
2010-07-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:cec096e7-53ee-44ea-80cc-22341df7fc40
Source identifiers:
383421
Local pid:
pubs:383421

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