Journal article
Nutlin-3, the small-molecule inhibitor of MDM2, promotes senescence and radiosensitises laryngeal carcinoma cells harbouring wild-type p53.
- Abstract:
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BACKGROUND: Primary radiotherapy (RT) is a mainstay of treatment for laryngeal squamous cell carcinoma (LSCC). Although the cure rates for early (T1) vocal cord tumours are high, RT proves ineffective in up to a third of T3 carcinomas. Moreover, RT is associated with debilitating early- and late-treatment-related toxicity, thus finding means to de-escalate therapy, while retaining/augmenting therapeutic effectiveness, is highly desirable. p53 is a key mediator of radiation responses; we ther...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/sj.bjc.6605739
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Bibliographic Details
- Journal:
- British journal of cancer
- Volume:
- 103
- Issue:
- 2
- Pages:
- 186-195
- Publication date:
- 2010-07-01
- DOI:
- EISSN:
-
1532-1827
- ISSN:
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0007-0920
- Source identifiers:
-
383421
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:383421
- UUID:
-
uuid:cec096e7-53ee-44ea-80cc-22341df7fc40
- Local pid:
- pubs:383421
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2010
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