Double-stranded DNA translocation: structure and mechanism of hexameric FtsK.

Journal article

FtsK is a DNA translocase that coordinates chromosome segregation and cell division in bacteria. In addition to its role as activator of XerCD site-specific recombination, FtsK can translocate double-stranded DNA (dsDNA) rapidly and directionally and reverse direction. We present crystal structures of the FtsK motor domain monomer, showing that it has a RecA-like core, the FtsK hexamer, and also showing that it is a ring with a large central annulus and a dodecamer consisting of two hexamers,...

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Authors: Massey, T; Mercogliano, C; Yates, J; Sherratt, D; Löwe, J

• Publication status: Published
• Journal: Molecular cell
• Volume: 23
• Issue: 4
• Pages: 457-469
• Publication date: 2006-08-01
• DOI: 10.1016/j.molcel.2006.06.019
• EISSN: 1097-4164
• ISSN: 1097-2765
• Language: English
• Keywords: Escherichia coli; Rec A Recombinases; Escherichia coli Proteins; Membrane Proteins; Integrases; Models, Genetic; Recombination, Genetic; Crystallography, X-Ray; Pseudomonas aeruginosa; Hydrolysis; DNA Helicases; DNA, Bacterial; Adenosine Triphosphate; Models, Molecular; RNA Helicases; Nucleic Acid Conformation