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Double-stranded DNA translocation: structure and mechanism of hexameric FtsK.

Abstract:

FtsK is a DNA translocase that coordinates chromosome segregation and cell division in bacteria. In addition to its role as activator of XerCD site-specific recombination, FtsK can translocate double-stranded DNA (dsDNA) rapidly and directionally and reverse direction. We present crystal structures of the FtsK motor domain monomer, showing that it has a RecA-like core, the FtsK hexamer, and also showing that it is a ring with a large central annulus and a dodecamer consisting of two hexamers,...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Molecular cell More from this journal
Volume:
23
Issue:
4
Pages:
457-469
Publication date:
2006-08-01
DOI:
EISSN:
1097-4164
ISSN:
1097-2765

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