Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer's disease.

Journal article

BACKGROUND: Alternative gene transcript splicing permits a single gene to produce multiple proteins with varied functions. Bioinformatic investigations have identified numerous splice variants, but whether these transcripts are translated to functional proteins and the physiological significance of these alternative proteins are largely unknown. Through direct identification of splice variants associated with disease states, we can begin to address these questions and to elucidate their roles...

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Authors: Heinzen, E; Yoon, W; Weale, M; Sen, A; Wood, N

• Journal: Genome biology
• Volume: 8
• Issue: 3
• Pages: R32
• Publication date: 2007-01-01
• DOI: 10.1186/gb-2007-8-3-r32
• EISSN: 1465-6914
• ISSN: 1465-6906
• Language: English
• Keywords: Humans; Alternative Splicing; Polymerase Chain Reaction; Epilepsy, Temporal Lobe; Oligonucleotide Array Sequence Analysis; Ion Channels; Alzheimer Disease