- Abstract:
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Group II metabotropic glutamate receptor (mGluR) ligands are potential novel drugs for neurological and psychiatric disorders, but little is known about the effects of these compounds at synapses of the human cerebral cortex. Investigating the effects of neuropsychiatric drugs in human brain tissue with preserved synaptic circuits might accelerate the development of more potent and selective pharmacological treatments. We have studied the effects of group II mGluR activation on excitatory syn...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 3.6MB)
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- Publisher copy:
- 10.3389/fncel.2018.00508
-
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- Publisher:
- Frontiers Media Publisher's website
- Journal:
- Frontiers in Cellular Neuroscience Journal website
- Volume:
- 12
- Pages:
- Article: 508
- Publication date:
- 2019-01-08
- Acceptance date:
- 2018-12-07
- DOI:
- ISSN:
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1662-5102
- Pubs id:
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pubs:952075
- URN:
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uri:ceb8a8cc-312b-402c-84ea-2e9c1ca4f9ae
- UUID:
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uuid:ceb8a8cc-312b-402c-84ea-2e9c1ca4f9ae
- Local pid:
- pubs:952075
- Copyright holder:
- Bocchio, et al
- Copyright date:
- 2019
- Notes:
- © 2019 Bocchio, Lukacs, Stacey, Plaha, Apostolopoulos, Livermore, Sen, Ansorge, Gillies, Somogyi and Capogna. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Journal article
Group II metabotropic glutamate receptors mediate presynaptic inhibition of excitatory transmission in pyramidal neurons of the human cerebral cortex
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National Institute for Health Research
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