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Group II metabotropic glutamate receptors mediate presynaptic inhibition of excitatory transmission in pyramidal neurons of the human cerebral cortex

Abstract:

Group II metabotropic glutamate receptor (mGluR) ligands are potential novel drugs for neurological and psychiatric disorders, but little is known about the effects of these compounds at synapses of the human cerebral cortex. Investigating the effects of neuropsychiatric drugs in human brain tissue with preserved synaptic circuits might accelerate the development of more potent and selective pharmacological treatments. We have studied the effects of group II mGluR activation on excitatory syn...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fncel.2018.00508

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
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National Institute for Health Research More from this funder
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Cellular Neuroscience Journal website
Volume:
12
Pages:
Article: 508
Publication date:
2019-01-08
Acceptance date:
2018-12-07
DOI:
ISSN:
1662-5102
Pubs id:
pubs:952075
URN:
uri:ceb8a8cc-312b-402c-84ea-2e9c1ca4f9ae
UUID:
uuid:ceb8a8cc-312b-402c-84ea-2e9c1ca4f9ae
Local pid:
pubs:952075

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