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Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates.

Abstract:

The tunicamycins are archetypal nucleoside antibiotics targeting bacterial peptidoglycan biosynthesis and eukaryotic protein N-glycosylation. Understanding the biosynthesis of their unusual carbon framework may lead to variants with improved selectivity. Here, we demonstrate in vitro recapitulation of key sugar-manipulating enzymes from this pathway. TunA is found to exhibit unusual regioselectivity in the reduction of a key α,β-unsaturated ketone. The product of this reaction is shown to be ...

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Publication status:
Published

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Publisher copy:
10.1038/nchem.1351

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Journal:
Nature chemistry
Volume:
4
Issue:
7
Pages:
539-546
Publication date:
2012-07-01
DOI:
EISSN:
1755-4349
ISSN:
1755-4330
Source identifiers:
339833
Language:
English
Keywords:
Pubs id:
pubs:339833
UUID:
uuid:ceb5e0a1-f984-40d7-8e77-51db3923ddbe
Local pid:
pubs:339833
Deposit date:
2012-12-19

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