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Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2.

Abstract:

BACKGROUND: Genome-wide association studies have identified multiple genetic variants associated with susceptibility to prostate cancer (PrCa). In the two-stage Cancer Genetic Markers of Susceptibility prostate cancer scan, a single-nucleotide polymorphism (SNP), rs10486567, located within intron 2 of JAZF1 gene on chromosome 7p15.2, showed a promising association with PrCa overall (P=2.14x10(-6)), with a suggestion of stronger association with aggressive disease (P=1.2x10(-7)). METHODS: In t...

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Publication status:
Published

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Journal:
Cancer epidemiology, biomarkers and prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Volume:
19
Issue:
5
Pages:
1349-1355
Publication date:
2010-05-05
DOI:
EISSN:
1538-7755
ISSN:
1055-9965
URN:
uuid:ceb4a286-e408-4793-b73d-5ab39c7b7e9c
Source identifiers:
71321
Local pid:
pubs:71321

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