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Pancreatic L-Glutamine Administration Protects Pig Islets from Cold Ischemic Injury and Increases Resistance toward Inflammatory Mediators

Abstract:

The isolation and transplantation of porcine islets represent a future option for the treatment of type 1 diabetic patients. Stringent product release criteria and limited availability of transgenic and specific pathogen-free pigs will essentially require processing of explanted pig pancreata in specialized, possibly remote isolation facilities, whereby pancreata are exposed to cold ischemia due to prolonged tissue transit time. In the present study we investigated whether pancreas oxygenatio...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.3727/096368915x688623

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Surgical Sciences
Oxford college:
St Edmund Hall
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Surgical Sciences
Role:
Author
Publisher:
SAGE Publications Publisher's website
Journal:
JournalName Journal website
Volume:
25
Issue:
3
Pages:
531-538
Publication date:
2016-03-01
Acceptance date:
2015-07-15
DOI:
EISSN:
1555-3892
ISSN:
0963-6897
Pubs id:
pubs:532016
URN:
uri:ceaea2e1-489a-4c04-a25c-712479a5dacb
UUID:
uuid:ceaea2e1-489a-4c04-a25c-712479a5dacb
Local pid:
pubs:532016

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