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Effects of neuronal nitric oxide synthase on human coronary artery diameter and blood flow in vivo.

Abstract:

BACKGROUND: Nitric oxide (NO)-mediated local regulation of vascular tone is considered to involve endothelial NO synthase (eNOS). However, we recently reported that human forearm basal microvascular tone in vivo is tonically regulated by neuronal NO synthase (nNOS), in contrast to an acetylcholine-stimulated reduction in tone, which is eNOS dependent. Here, we investigated the in vivo effects of an nNOS-selective inhibitor, S-methyl-L-thiocitrulline (SMTC), on the human coronary circulation a...

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Publication status:
Published

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Journal:
Circulation More from this journal
Volume:
119
Issue:
20
Pages:
2656-2662
Publication date:
2009-05-01
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Language:
English
Keywords:
Pubs id:
pubs:105069
UUID:
uuid:ce95d0cf-4915-4df1-9585-db6ecfc13d3d
Local pid:
pubs:105069
Source identifiers:
105069
Deposit date:
2012-12-19

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