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The distribution of haemoglobin C and its prevalence in newborns in Africa

Abstract:

Haemoglobin C (HbC) is one of the commonest structural haemoglobin variants in human populations. Although HbC causes mild clinical complications, its diagnosis and genetic counselling are important to prevent inheritance with other haemoglobinopathies. Little is known about its contemporary distribution and the number of newborns affected. We assembled a global database of population surveys. We then used a Bayesian geostatistical model to create maps of HbC frequency across Africa and paire...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep01671

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More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Big Data Institute
Role:
Author
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
3
Article number:
1671
Publication date:
2013-04-17
Acceptance date:
2013-04-02
DOI:
EISSN:
2045-2322
Language:
English
Keywords:
UUID:
uuid:ce951680-0485-4679-b314-f3c1e2ea1eba
Local pid:
pubs:395928
Source identifiers:
395928
Deposit date:
2013-11-16

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