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The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site.

Abstract:

The neurotrophins are growth factors that are involved in the development and survival of neurons. Neurotrophin release by a target tissue results in neuron growth along the neurotrophin concentration gradient, culminating in the eventual innervation of the target tissue. These activities are mediated through trk cell surface receptors. We have determined the structures of the heterodimer formed between brain-derived neurotrophic factor (BDNF) and neurotrophin 4 (NT4), as well as the structur...

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Publication status:
Published

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Publisher copy:
10.1110/ps.8.12.2589

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Journal:
Protein science : a publication of the Protein Society More from this journal
Volume:
8
Issue:
12
Pages:
2589-2597
Publication date:
1999-12-01
DOI:
EISSN:
1469-896X
ISSN:
0961-8368
Language:
English
Keywords:
Pubs id:
pubs:954
UUID:
uuid:ce917999-14f1-4fb7-86d7-68cf9fed6b6d
Local pid:
pubs:954
Source identifiers:
954
Deposit date:
2012-12-19

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