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A structural basis for antibody-mediated neutralization of Nipah virus reveals a site of vulnerability at the fusion glycoprotein apex

Abstract:

Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes frequent outbreaks of severe neurologic and respiratory disease in humans with high case fatality rates. The 2 glycoproteins displayed on the surface of the virus, NiV-G and NiV-F, mediate host-cell attachment and membrane fusion, respectively, and are targets of the host antibody response. Here, we provide a molecular basis for neutralization of NiV through antibody-mediated targeting of NiV-F. Structural characterization of ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1912503116

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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
116
Issue:
50
Pages:
25057-25067
Publication date:
2019-11-25
Acceptance date:
2019-10-30
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
31767754
Source identifiers:
1075614
Language:
English
Keywords:
Pubs id:
pubs:1075614
UUID:
uuid:ce84bba0-f492-4d27-a05a-e6af7ea65fee
Local pid:
pubs:1075614
Deposit date:
2019-12-05

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