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A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.

Abstract:

Capacitance measurements were applied to mouse pancreatic beta-cells to elucidate the cellular mechanisms underlying biphasic insulin secretion. We report here that only <50 of the beta-cell's >10,000 granules are immediately available for release. The releasable granules tightly associate with the voltage-gated alpha(1C) Ca(2+) channels, and it is proposed that the release of these granules accounts for first-phase insulin secretion. Subsequent replenishment of the releasable pool by p...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Diabetes More from this journal
Volume:
51 Suppl 1
Issue:
SUPPL.
Pages:
S74-S82
Publication date:
2002-02-01
Event title:
2nd Servier-IGIS Symposium
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Keywords:
Pubs id:
pubs:24457
UUID:
uuid:ce6ef7f1-107e-46de-a7b2-3a64b8337588
Local pid:
pubs:24457
Source identifiers:
24457
Deposit date:
2012-12-19

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