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Elevation of iron storage in humans attenuates the pulmonary vascular response to hypoxia

Abstract:

Sustained hypoxia over several hours induces a progressive rise in pulmonary artery systolic pressure (PASP). Administration of intravenous iron immediately prior to the hypoxia exposure abrogates this effect, suggesting that manipulation of iron stores may modify hypoxia-induced pulmonary hypertension. Iron (ferric carboxymaltose) administered intravenously has a plasma half-life of 7-12 h. Thus any therapeutic use of intravenous iron would require its effect on PASP to persist long after th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1152/japplphysiol.00032.2016

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
ORCID:
0000-0002-6162-4146
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
ORCID:
0000-0001-5384-175X
More from this funder
Name:
Academy of Medical Sciences
Grant:
AMS-SGCL11-Petousi
More from this funder
Name:
Department of Health
Grant:
CL-2013-13-003
More from this funder
Name:
National Institute for Health Research
Grant:
CL-2013-13-003
More from this funder
Name:
Sir John Monash Scholarship, Avant Scholarship
Publisher:
American Physiological Society
Journal:
Journal of Applied Physiology More from this journal
Volume:
121
Issue:
2
Pages:
537-544
Publication date:
2016-08-01
Acceptance date:
2016-07-07
DOI:
EISSN:
1522-1601
ISSN:
8750-7587
Pmid:
27418684
Language:
English
Keywords:
Pubs id:
pubs:635440
UUID:
uuid:ce6a5484-f914-477e-9194-3818d32a7689
Local pid:
pubs:635440
Source identifiers:
635440
Deposit date:
2018-05-14

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