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Effect of filtrate containing Clostridium difficile toxin on rectal mucosa maintained in organ culture.

Abstract:

Rectal biopsies were maintained in organ culture over a 24-hour culture period, with good preservation of histological architecture. A filtrate containing Clostridium difficile toxin significantly inhibited the rise in epithelial alkaline phosphatase activity normally seen during culture. This effect was abolished by pre-incubation of the filtrate with Clostridium sordellii antitoxin, or heat inactivation. This effect is most probably due to a toxin of C. difficile. The method provides a new ...

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Publication status:
Published

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Publisher copy:
10.1159/000199212
Journal:
Digestion More from this journal
Volume:
32
Issue:
1
Pages:
25-29
Publication date:
1985-01-01
DOI:
EISSN:
1421-9867
ISSN:
0012-2823
Language:
English
Keywords:
Pubs id:
pubs:135749
UUID:
uuid:ce634bb4-11f8-41cd-a199-a6db4e9cf379
Local pid:
pubs:135749
Source identifiers:
135749
Deposit date:
2012-12-19

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