Lower cellular immune responses to influenza A (H3N2) in the elderly.

Journal article

Influenza epidemic is an important cause of severe illness in the elderly. Age-dependent morbidity of influenza in the elderly is associated with weakened immunity. The baseline age-related memory T cell activity in Chinese persons who are exposed to influenza virus through natural infection, are associated with the protective response to the virus after vaccination, thus providing important pre-vaccination information. A cohort from the general population was established at the end of an inf...

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Authors: Jia, N; Li, C; Liu, Y; Richardus, J; Feng, D

• Publication status: Published
• Journal: Journal of medical virology
• Volume: 81
• Issue: 8
• Pages: 1471-1476
• Publication date: 2009-08-01
• DOI: 10.1002/jmv.21544
• EISSN: 1096-9071
• ISSN: 0146-6615
• Language: English
• Keywords: Interferon-gamma; Cohort Studies; Young Adult; Antibodies, Viral; Hemagglutination Inhibition Tests; Aged; Humans; Aged, 80 and over; Age Factors; Female; Influenza, Human; Male; T-Lymphocyte Subsets; Influenza A Virus, H3N2 Subtype; Immunologic Memory; Adult; China; Middle Aged