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PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome.

Abstract:

Previous work has shown that the protein kinase A (PKA)-regulated phosphodiesterase (PDE) 4D3 binds to A kinase-anchoring proteins (AKAPs). One such protein, AKAP9, localizes to the centrosome. In this paper, we investigate whether a PKA-PDE4D3-AKAP9 complex can generate spatial compartmentalization of cyclic adenosine monophosphate (cAMP) signaling at the centrosome. Real-time imaging of fluorescence resonance energy transfer reporters shows that centrosomal PDE4D3 modulated a dynamic microd...

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Publication status:
Published

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Publisher copy:
10.1083/jcb.201201059

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Journal:
Journal of cell biology More from this journal
Volume:
198
Issue:
4
Pages:
607-621
Publication date:
2012-08-01
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Language:
English
Keywords:
Pubs id:
pubs:349888
UUID:
uuid:ce5ffd74-e8cb-480b-8971-78100d22887b
Local pid:
pubs:349888
Source identifiers:
349888
Deposit date:
2013-11-16

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