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GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain

Abstract:

Extracellular vesicles (EVs) are biological nanoparticles with important roles in intercellular communication, and potential as drug delivery vehicles. Here we demonstrate a role for the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in EV assembly and secretion. We observe high levels of GAPDH binding to the outer surface of EVs via a phosphatidylserine binding motif (G58), which promotes extensive EV clustering. Further studies in a Drosophila EV biogenesis model reve...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-021-27056-3

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Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
ORCID:
0000-0003-0761-5676
More by this author
Institution:
University of Oxford
Role:
Author
ORCID:
0000-0001-9728-254X
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Institution:
University of Oxford
Role:
Author
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Name:
Medical Research Council
Grant:
MR/M007715/1
MC_PC_17174
More from this funder
Name:
Biotechnology & Biological Sciences Research Council
Grant:
BB/N016300/1
BB/R004862/1
BB/K017462/1
Publisher:
Nature Research
Journal:
Nature Communications More from this journal
Volume:
12
Issue:
1
Article number:
6666
Publication date:
2021-11-18
Acceptance date:
2021-10-17
DOI:
EISSN:
2041-1723
Pmid:
34795295
Language:
English
Keywords:
Pubs id:
1211138
Local pid:
pubs:1211138
Deposit date:
2022-11-11

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