- Abstract:
-
OBJECTIVE: Chronic exposure to elevated glucocorticoid (GC) concentrations induces detrimental effects in several tissues. In the skin, GCs provoke intense alterations on various parameters of the physiology of fibroblasts, cumulatively leading to skin atrophy and impaired wound healing. As there are concerns that GCs may generate permanent adverse functional changes, we have investigated whether chronic in vivo exposure to GC excess results in persisting defects in skin fibroblasts. DESIGN ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1530/eje.1.01913
-
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- Journal:
- European journal of endocrinology / European Federation of Endocrine Societies
- Volume:
- 152
- Issue:
- 6
- Pages:
- 895-902
- Publication date:
- 2005-06-05
- DOI:
- EISSN:
-
1479-683X
- ISSN:
-
0804-4643
- URN:
-
uuid:ce50e35e-a79e-41e2-9dfa-478dce0dadec
- Source identifiers:
-
111326
- Local pid:
- pubs:111326
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
The impact of chronic in vivo glucocorticoid excess on the functional characteristics of human skin fibroblasts obtained from patients with endogenous Cushing's syndrome.
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