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The impact of chronic in vivo glucocorticoid excess on the functional characteristics of human skin fibroblasts obtained from patients with endogenous Cushing's syndrome.

Abstract:

OBJECTIVE: Chronic exposure to elevated glucocorticoid (GC) concentrations induces detrimental effects in several tissues. In the skin, GCs provoke intense alterations on various parameters of the physiology of fibroblasts, cumulatively leading to skin atrophy and impaired wound healing. As there are concerns that GCs may generate permanent adverse functional changes, we have investigated whether chronic in vivo exposure to GC excess results in persisting defects in skin fibroblasts. DESIGN ...

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Publication status:
Published

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Publisher copy:
10.1530/eje.1.01913

Authors


Zervolea, I More by this author
Pratsinis, H More by this author
Tsagarakis, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Stathakos, D More by this author
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Journal:
European journal of endocrinology / European Federation of Endocrine Societies
Volume:
152
Issue:
6
Pages:
895-902
Publication date:
2005-06-05
DOI:
EISSN:
1479-683X
ISSN:
0804-4643
URN:
uuid:ce50e35e-a79e-41e2-9dfa-478dce0dadec
Source identifiers:
111326
Local pid:
pubs:111326

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