- Abstract:
-
HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. Recent studies have defined posttranslational modification by prolyl hydroxylation as a key regulatory event that targets HIF-alpha subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Here, we define a conserved HIF-VHL-prolyl hydroxylase pathway in C. elegans, and use a genetic approach to identify EGL-9 as a dioxygenase that regulates HIF by prolyl hydroxylation. In...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0092-8674(01)00507-4
-
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- Journal:
- Cell
- Volume:
- 107
- Issue:
- 1
- Pages:
- 43-54
- Publication date:
- 2001-10-05
- DOI:
- EISSN:
-
1097-4172
- ISSN:
-
0092-8674
- URN:
-
uuid:ce4fb80f-140e-4d46-8e34-2416b29ab0f0
- Source identifiers:
-
2813
- Local pid:
- pubs:2813
- Language:
- English
- Keywords:
- Copyright date:
- 2001
Journal article
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
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