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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

Abstract:

HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. Recent studies have defined posttranslational modification by prolyl hydroxylation as a key regulatory event that targets HIF-alpha subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Here, we define a conserved HIF-VHL-prolyl hydroxylase pathway in C. elegans, and use a genetic approach to identify EGL-9 as a dioxygenase that regulates HIF by prolyl hydroxylation. In...

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Publication status:
Published

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Authors


Epstein, AC More by this author
Gleadle, JM More by this author
McNeill, LA More by this author
Hewitson, KS More by this author
O'Rourke, J More by this author
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Journal:
Cell
Volume:
107
Issue:
1
Pages:
43-54
Publication date:
2001-10-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:ce4fb80f-140e-4d46-8e34-2416b29ab0f0
Source identifiers:
2813
Local pid:
pubs:2813

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