Journal article
The deubiquitylase USP9X controls ribosomal stalling
- Abstract:
-
When a ribosome stalls during translation, it runs the risk of collision with a trailing ribosome. Such an encounter leads to the formation of a stable di-ribosome complex, which needs to be resolved by a dedicated machinery. The initial stalling and the subsequent resolution of di-ribosomal complexes requires activity of Makorin and ZNF598 ubiquitin E3 ligases, respectively, through ubiquitylation of the eS10 and uS10 subunits of the ribosome. We have developed a specific small-molecule inhi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Rockefeller University Press Publisher's website
- Journal:
- Journal of Cell Biology Journal website
- Volume:
- 220
- Issue:
- 3
- Article number:
- e202004211
- Publication date:
- 2021-01-28
- Acceptance date:
- 2020-12-11
- DOI:
- EISSN:
-
1540-8140
- ISSN:
-
0021-9525
- Pmid:
-
33507233
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1159133
- Local pid:
- pubs:1159133
- Deposit date:
- 2021-03-17
Terms of use
- Copyright holder:
- A Clancy et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 Clancy et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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