Xpf suppresses the mutagenic consequences of phagocytosis in Dictyostelium

Journal article

As time passes, mutations accumulate in the genomes of all living organisms. These changes promote genetic diversity, but also precipitate ageing and the initiation of cancer. Food is a common source of mutagens, but little is known about how nutritional factors cause lasting genetic changes in the consuming organism. Here, we describe an unusual genetic interaction between DNA repair in the unicellular amoeba Dictyostelium discoideum and its natural bacterial food source. We found that Dicty...

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Authors: Pontel, LB; Langenick, J; Rosado, IV; Zhang, X; Traynor, D

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: The Company of Biologists
• Journal: Journal of Cell Science
• Volume: 129
• Issue: 24
• Pages: 4449-4454
• Publication date: 2016-12-15
• Acceptance date: 2016-11-01
• DOI: 10.1242/jcs.196337
• EISSN: 1477-9137
• ISSN: 0021-9533
• Language: English
• Keywords: Mutagenesis; DNA repair; Dictyostelium; Xpf; Phagocytosis