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Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease.

Abstract:

The chemokine system represents a diverse group of G protein-coupled receptors responsible for orchestrating cell recruitment under both homeostatic and inflammatory conditions. Chemokine receptor 9 (CCR9) is a chemokine receptor known to be central for migration of immune cells into the intestine. Its only ligand, CCL25, is expressed at the mucosal surface of the intestine and is known to be elevated in intestinal inflammation. To date, there are no reports of small-molecule antagonists targ...

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Publication status:
Published

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Publisher copy:
10.1124/jpet.110.169714

Authors


Walters, MJ More by this author
Baumgart, T More by this author
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Journal:
The Journal of pharmacology and experimental therapeutics
Volume:
335
Issue:
1
Pages:
61-69
Publication date:
2010-10-05
DOI:
EISSN:
1521-0103
ISSN:
0022-3565
URN:
uuid:ce3b2583-552f-40e5-bebf-39b27cb90c3b
Source identifiers:
66515
Local pid:
pubs:66515

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