- Abstract:
-
The chemokine system represents a diverse group of G protein-coupled receptors responsible for orchestrating cell recruitment under both homeostatic and inflammatory conditions. Chemokine receptor 9 (CCR9) is a chemokine receptor known to be central for migration of immune cells into the intestine. Its only ligand, CCL25, is expressed at the mucosal surface of the intestine and is known to be elevated in intestinal inflammation. To date, there are no reports of small-molecule antagonists targ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1124/jpet.110.169714
-
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- Journal:
- The Journal of pharmacology and experimental therapeutics
- Volume:
- 335
- Issue:
- 1
- Pages:
- 61-69
- Publication date:
- 2010-10-05
- DOI:
- EISSN:
-
1521-0103
- ISSN:
-
0022-3565
- URN:
-
uuid:ce3b2583-552f-40e5-bebf-39b27cb90c3b
- Source identifiers:
-
66515
- Local pid:
- pubs:66515
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease.
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