Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Journal article

Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiple...

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Authors: Sawcer, S; Hellenthal, G; Pirinen, M; Spencer, C; Patsopoulos, N

• Publication status: Published
• Journal: Nature
• Volume: 476
• Issue: 7359
• Pages: 214-219
• Publication date: 2011-08-01
• DOI: 10.1038/nature10251
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Sample Size; T-Lymphocytes, Helper-Inducer; Multiple Sclerosis; HLA-DRB1 Chains; Genetic Predisposition to Disease; Wellcome Trust Case Control Consortium 2; Polymorphism, Single Nucleotide; Alleles; Cell Differentiation; HLA-A Antigens; Humans; Immunity, Cellular; Genome-Wide Association Study; Major Histocompatibility Complex; Genome, Human; International Multiple Sclerosis Genetics Consortium; HLA-DR Antigens; Europe