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Protein kinase A type I and type II define distinct intracellular signaling compartments.

Abstract:

Protein kinase A (PKA) is a key regulatory enzyme that, on activation by cAMP, modulates a wide variety of cellular functions. PKA isoforms type I and type II possess different structural features and biochemical characteristics, resulting in nonredundant function. However, how different PKA isoforms expressed in the same cell manage to perform distinct functions on activation by the same soluble intracellular messenger, cAMP, remains to be established. Here, we provide a mechanism for the di...

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Journal:
Circulation research More from this journal
Volume:
103
Issue:
8
Pages:
836-844
Publication date:
2008-10-01
DOI:
EISSN:
1524-4571
ISSN:
0009-7330

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