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Journal article

ASPP1 deficiency promotes epithelial-mesenchymal transition, invasion and metastasis in colorectal cancer

Abstract:

The apoptosis-stimulating protein of p53 (ASPP) family of proteins can regulate apoptosis by interacting with the p53 family and have been identified to play an important role in cancer progression. Previously, we have demonstrated that ASPP2 downregulation can promote invasion and migration by controlling β-catenin-dependent regulation of ZEB1, however, the role of ASPP1 in colorectal cancer (CRC) remains unclear. We analyzed data from The Cancer Genome Atlas (TCGA) and coupled this to in vi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41419-020-2415-2

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Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
Cell Death and Disease Journal website
Volume:
11
Article number:
224
Publication date:
2020-04-08
Acceptance date:
2020-03-18
DOI:
EISSN:
2041-4889
Language:
English
Keywords:
Pubs id:
1095396
Local pid:
pubs:1095396
Deposit date:
2020-03-20

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