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Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double-blind, dose-ranging trial.

Abstract:

BACKGROUND: Primaquine is the only available drug that clears mature Plasmodium falciparum gametocytes in infected human hosts, thereby preventing transmission of malaria to mosquitoes. However, concerns about dose-dependent haemolysis in people with glucose-6-phosphate dehydrogenase (G6PD) deficiencies have limited its use. We assessed the dose-response association of single-dose primaquine for gametocyte clearance and for safety in P falciparum malaria. METHODS: We undertook this randomised...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/s1473-3099(13)70268-8

Authors


Eziefula, AC More by this author
Bousema, T More by this author
Owaraganise, A More by this author
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Publisher:
Elsevier Ltd. Publisher's website
Journal:
The Lancet. Infectious diseases Journal website
Volume:
14
Issue:
2
Pages:
130-139
Publication date:
2014-02-05
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
URN:
uuid:ce2a62a8-53cf-4ae8-9e37-8c58a848c3a3
Source identifiers:
440928
Local pid:
pubs:440928

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