Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double-blind, dose-ranging trial.

Journal article

BACKGROUND: Primaquine is the only available drug that clears mature Plasmodium falciparum gametocytes in infected human hosts, thereby preventing transmission of malaria to mosquitoes. However, concerns about dose-dependent haemolysis in people with glucose-6-phosphate dehydrogenase (G6PD) deficiencies have limited its use. We assessed the dose-response association of single-dose primaquine for gametocyte clearance and for safety in P falciparum malaria. METHODS: We undertook this randomised...

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Authors: Eziefula, A; Bousema, T; Yeung, S; Kamya, M; Owaraganise, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier Publisher's website
• Journal: Lancet. Infectious diseases Journal website
• Volume: 14
• Issue: 2
• Pages: 130-139
• Publication date: 2014-02-01
• DOI: 10.1016/s1473-3099(13)70268-8
• EISSN: 1474-4457
• ISSN: 1473-3099
• Language: English
• Keywords: Infant; Male; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorenes; Ethanolamines; Drug Combinations; Parasite Load; Malaria, Falciparum; Child, Preschool; Treatment Outcome; Uganda; Artemisinins; Follow-Up Studies; Double-Blind Method; Primaquine; Humans; ROC Curve; Antimalarials; Child