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Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double-blind, dose-ranging trial.

Abstract:

BACKGROUND: Primaquine is the only available drug that clears mature Plasmodium falciparum gametocytes in infected human hosts, thereby preventing transmission of malaria to mosquitoes. However, concerns about dose-dependent haemolysis in people with glucose-6-phosphate dehydrogenase (G6PD) deficiencies have limited its use. We assessed the dose-response association of single-dose primaquine for gametocyte clearance and for safety in P falciparum malaria. METHODS: We undertook this randomised...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/s1473-3099(13)70268-8

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Publisher:
Elsevier Publisher's website
Journal:
Lancet. Infectious diseases Journal website
Volume:
14
Issue:
2
Pages:
130-139
Publication date:
2014-02-01
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
Source identifiers:
440928

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