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Journal article

The broad assessment of HCV genotypes 1 and 3 antigenic targets reveals limited cross-reactivity with implications for vaccine design.

Abstract:

OBJECTIVE: Developing a vaccine that is cross-reactive between HCV genotypes requires data on T cell antigenic targets that extends beyond genotype-1. We characterised T cell immune responses against HCV genotype-3, the most common infecting genotype in the UK and Asia, and assessed within genotype and between genotype cross-reactivity. DESIGN: T cell targets were identified in 140 subjects with either acute, chronic or spontaneously resolved HCV genotype-3 infection using (1) overlapping pep...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More from this funder
Name:
Oxford Martin School
Funding agency for:
Barnes, E
More from this funder
Name:
The Jenner Institute
Funding agency for:
Barnes, E
More from this funder
Name:
NIHR Biomedical Research Centre, Oxford
Funding agency for:
Barnes, E
More from this funder
Name:
Medical Research Council
Funding agency for:
von Delft, A
Humphreys, I
Barnes, E
Journal:
Gut More from this journal
Publication date:
2015-06-19
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
Language:
English
Keywords:
Pubs id:
pubs:528593
UUID:
uuid:ce26884d-740b-4c69-adb6-d8bff173d6c7
Local pid:
pubs:528593
Source identifiers:
528593
Deposit date:
2015-09-18

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