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Proteomic analysis of resting and thrombin-stimulated platelets reveals the translocation and functional relevance of HIP-55 in platelets.

Abstract:

The platelet surface is a dynamic interface that changes rapidly in response to stimuli to co-ordinate the formation of thrombi at sites of vascular injury. Tight control is essential as loss of organisation may result in the inappropriate formation of thrombi (thrombosis) or excessive bleeding. In this paper we describe the comparative analysis of resting and thrombin-stimulated platelet membrane proteomes and associated proteins to identify proteins important to platelet function. Surface p...

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Publication status:
Published

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Publisher copy:
10.1002/pmic.200900024

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Journal:
Proteomics
Volume:
9
Issue:
18
Pages:
4340-4354
Publication date:
2009-09-05
DOI:
EISSN:
1615-9861
ISSN:
1615-9853
URN:
uuid:ce1f412d-1e51-4873-a77f-61bc01cb8c3d
Source identifiers:
244372
Local pid:
pubs:244372

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