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PP1 promotes cyclin B destruction and the metaphase-anaphase transition by dephosphorylating CDC20

Abstract:

Ubiquitin-dependent proteolysis of cyclin B and securin initiates sister chromatid segregation and anaphase. The anaphase promoting complex/cyclosome and its co-activator CDC20 (APC/CCDC20) form the main ubiquitin E3 ligase for these two proteins. APC/CCDC20 is regulated by CDK1-cyclin B and counteracting PP1 and PP2A family phosphatases through modulation of both activating and inhibitory phosphorylation. Here, we report that PP1 promotes cyclin B destruction at the onset of anaphase by remo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1091/mbc.e20-04-0252

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Name:
Medical Research Council
Grant:
MR/K006703/1
More from this funder
Name:
Edward Penley Abraham Research Fund
Grant:
RF 249
More from this funder
Name:
Biotechnology & Biological Sciences Research Council
Grant:
BB/M00354X/1
Publisher:
American Society for Cell Biology
Journal:
Molecular Biology of the Cell More from this journal
Volume:
31
Issue:
21
Pages:
2289-2408
Publication date:
2020-09-29
Acceptance date:
2020-07-29
DOI:
EISSN:
1939-4586
Pmid:
32755477
Language:
English
Keywords:
Pubs id:
1124686
Local pid:
pubs:1124686
Deposit date:
2020-08-28

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