Journal article
PP1 promotes cyclin B destruction and the metaphase-anaphase transition by dephosphorylating CDC20
- Abstract:
-
Ubiquitin-dependent proteolysis of cyclin B and securin initiates sister chromatid segregation and anaphase. The anaphase promoting complex/cyclosome and its co-activator CDC20 (APC/CCDC20) form the main ubiquitin E3 ligase for these two proteins. APC/CCDC20 is regulated by CDK1-cyclin B and counteracting PP1 and PP2A family phosphatases through modulation of both activating and inhibitory phosphorylation. Here, we report that PP1 promotes cyclin B destruction at the onset of anaphase by remo...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- American Society for Cell Biology Publisher's website
- Journal:
- Molecular Biology of the Cell Journal website
- Volume:
- 31
- Issue:
- 21
- Pages:
- 2289-2408
- Publication date:
- 2020-09-29
- Acceptance date:
- 2020-07-29
- DOI:
- EISSN:
-
1939-4586
- Pmid:
-
32755477
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1124686
- Local pid:
- pubs:1124686
- Deposit date:
- 2020-08-28
Terms of use
- Copyright holder:
- Bancroft, Holder, Geraghty, et al.
- Copyright date:
- 2020
- Rights statement:
- ©2020 Bancroft, Holder, Geraghty, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).
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