Journal article icon

Journal article

Decreased STARD10 expression is associated with defective insulin secretion in humans and mice.

Abstract:

Genetic variants near ARAP1 (CENTD2) and STARD10 influence type 2 diabetes (T2D) risk. The risk alleles impair glucose-induced insulin secretion and, paradoxically but characteristically, are associated with decreased proinsulin:insulin ratios, indicating improved proinsulin conversion. Neither the identity of the causal variants nor the gene(s) through which risk is conferred have been firmly established. Whereas ARAP1 encodes a GTPase activating protein, STARD10 is a member of the steroidog...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.ajhg.2017.01.011

Authors


Expand authors...
More from this funder
Funding agency for:
van de Bunt, M
Grant:
Postdoctoral fellowship
More from this funder
Funding agency for:
Gloyn, A
Grant:
095101/Z/10/Z
More from this funder
Funding agency for:
McCarthy, M
Grant:
MR/L020149/1
More from this funder
Funding agency for:
McCarthy, M
Grant:
MR/L020149/1
More from this funder
Funding agency for:
McCarthy, M
Grant:
MR/L020149/1
Expand funders...
Publisher:
Elsevier Publisher's website
Journal:
American Journal of Human Genetics Journal website
Volume:
100
Issue:
2
Pages:
238-256
Publication date:
2017-01-01
Acceptance date:
2016-12-20
DOI:
ISSN:
1537-6605 and 0002-9297
Source identifiers:
675100
Language:
English
Keywords:
Pubs id:
pubs:675100
UUID:
uuid:ce18cc5c-70ac-4824-936a-76ecd8bdd211
Local pid:
pubs:675100
Deposit date:
2017-03-02

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP