Journal article icon

Journal article

Decreased STARD10 expression is associated with defective insulin secretion in humans and mice.

Abstract:

Genetic variants near ARAP1 (CENTD2) and STARD10 influence type 2 diabetes (T2D) risk. The risk alleles impair glucose-induced insulin secretion and, paradoxically but characteristically, are associated with decreased proinsulin:insulin ratios, indicating improved proinsulin conversion. Neither the identity of the causal variants nor the gene(s) through which risk is conferred have been firmly established. Whereas ARAP1 encodes a GTPase activating protein, STARD10 is a member of the steroidog...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1016/j.ajhg.2017.01.011

Authors


Carrat, GR More by this author
Nguyen-Tu, M-S More by this author
Chabosseau, P More by this author
Gaulton, KJ More by this author
Expand authors...
More from this funder
Funding agency for:
van de Bunt, M
More from this funder
Funding agency for:
Gloyn, AL
More from this funder
Funding agency for:
McCarthy, M
More from this funder
Funding agency for:
McCarthy, M
Expand funders...
Publisher:
Elsevier Publisher's website
Journal:
American Journal of Human Genetics Journal website
Volume:
100
Issue:
2
Pages:
238-256
Publication date:
2017-01-05
Acceptance date:
2016-12-20
DOI:
ISSN:
0002-9297 and 1537-6605
Pubs id:
pubs:675100
URN:
uri:ce18cc5c-70ac-4824-936a-76ecd8bdd211
UUID:
uuid:ce18cc5c-70ac-4824-936a-76ecd8bdd211
Local pid:
pubs:675100

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP