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Potential therapeutic effects of oral bisphosphonates on the intestine.

Abstract:

Bisphosphonates are the principal drugs prescribed for the prevention of osteoporotic fractures. They are bone specific but poorly absorbed. In oral formulations, almost 99% of the administered dose remains within the intestinal tract and reaches the small and large bowel. Although the nitrogen-containing bisphosphonates can irritate the distal esophageal/gastric mucosa, they improve drug-induced colitis in animal models and exhibit antitumor properties on intestinal cells in vitro. Several r...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Annals of the New York Academy of Sciences
Volume:
1240
Issue:
1
Pages:
E19-E25
Publication date:
2011-12-05
DOI:
EISSN:
1749-6632
ISSN:
0077-8923
URN:
uuid:ce0ec741-d7e5-4e60-9b08-960873248c96
Source identifiers:
312884
Local pid:
pubs:312884

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