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Alternating modulation of subthalamic nucleus beta oscillations during stepping

Abstract:

Gait disturbances in Parkinson’s disease are commonly refractory to current treatment options and majorly impair patient’s quality of life. Auditory cues facilitate gait and prevent motor blocks. We investigated how neural dynamics in the human subthalamic nucleus of Parkinsons’s disease patients (14 male, 2 female) vary during stepping and whether rhythmic auditory cues enhance the observed modulation. Oscillations in the beta band were suppressed after ipsilateral heel strikes, when the con...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1523/JNEUROSCI.3596-17.2018

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Little, S
Grant:
105804/Z/14/Z
More from this funder
Name:
Medical Research Council
Funding agency for:
Tan, H
Grant:
MR/P012272/1
MC_UU_12024/1
More from this funder
Name:
European Union
Funding agency for:
Herz, D
Grant:
655605
More from this funder
Name:
Ministry of Science and Technology in Taiwan
Funding agency for:
Chang, Y
Grant:
106-2917-I-564-027
More from this funder
Name:
St. John’s College, Oxford
Funding agency for:
Fischer, P
Publisher:
Society for Neuroscience
Journal:
Journal of Neuroscience More from this journal
Volume:
38
Issue:
22
Pages:
5111-5121
Publication date:
2018-05-30
Acceptance date:
2018-04-24
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Pubs id:
pubs:844190
UUID:
uuid:ce0da488-1077-459a-82e6-ff97222d4dba
Local pid:
pubs:844190
Source identifiers:
844190
Deposit date:
2018-04-25

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