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Biological function of the soluble CEACAM1 protein and implications in TAP2-deficient patients.

Abstract:

Interactions of natural killer (NK) cells with MHC class I proteins provide the main inhibitory signals controlling NK killing activity. It is therefore surprising to learn that TAP2-deficient patients suffer from autoimmune manifestations only occasionally in later stages of life. We have previously described that the CEACAM1-mediated inhibitory mechanism of NK cytotoxicity plays a major role in controlling NK autoreactivity in three newly identified TAP2-deficient siblings. This novel mecha...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200425021

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Journal:
European journal of immunology More from this journal
Volume:
34
Issue:
8
Pages:
2138-2148
Publication date:
2004-08-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Language:
English
Keywords:
Pubs id:
pubs:32781
UUID:
uuid:ce05c86a-25ae-4866-abf0-94c4e815fb17
Local pid:
pubs:32781
Source identifiers:
32781
Deposit date:
2012-12-19

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