Biological function of the soluble CEACAM1 protein and implications in TAP2-deficient patients.

Journal article

Interactions of natural killer (NK) cells with MHC class I proteins provide the main inhibitory signals controlling NK killing activity. It is therefore surprising to learn that TAP2-deficient patients suffer from autoimmune manifestations only occasionally in later stages of life. We have previously described that the CEACAM1-mediated inhibitory mechanism of NK cytotoxicity plays a major role in controlling NK autoreactivity in three newly identified TAP2-deficient siblings. This novel mecha...

Expand abstract

Authors: Markel, G; Achdout, H; Katz, G; Ling, K; Salio, M

• Publication status: Published
• Journal: European journal of immunology
• Volume: 34
• Issue: 8
• Pages: 2138-2148
• Publication date: 2004-08-01
• DOI: 10.1002/eji.200425021
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Histocompatibility Antigens Class I; Pedigree; Humans; ATP-Binding Cassette Transporters; Cell Adhesion Molecules; Female; Antigens, CD; Killer Cells, Natural; Male; Major Histocompatibility Complex; Metalloproteases; Antigens, Differentiation