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Sexual dimorphism in the synchrony of joint growth hormone and cortisol dynamics in children with classic 21-hydroxylase deficiency.

Abstract:

In humans, growth hormone (GH) and cortisol are secreted in a pulsatile fashion and a mutual bidirectional interaction between the GH/insulin-like growth factor (IGF)-I axis and hypothalamic-pituitary-adrenal (HPA) axis has been established. Classic congenital adrenal hyperplasia (CAH) is characterized by a defect in the synthesis of glucocorticoids and often mineralocorticoids, and adrenal hyperandrogenism. In view of the sexually dimorphic pattern in GH secretion, we investigated the GH-cor...

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Publication status:
Published

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Publisher copy:
10.1515/jpem.2003.16.8.1119

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Journal:
Journal of pediatric endocrinology and metabolism : JPEM More from this journal
Volume:
16
Issue:
8
Pages:
1119-1130
Publication date:
2003-01-01
DOI:
EISSN:
2191-0251
ISSN:
0334-018X

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