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Reversible ligation of programmed DNA-gold nanoparticle assemblies

Abstract:

We demonstrate a new method to reversibly cross-link DNA-nanoparticle dimers, trimers, and tetramers using light as an external stimulus. A DNA interstrand photo-cross-linking reaction is possible via ligation of a cyano-vinyl carbazole nucleoside with an opposite thymine when irradiated at 365 nm. This reaction results in nanoparticle assemblies that are not susceptible to DNA dehybridization conditions. The chemical bond between the two complementary DNA strands can be reversibly broken upo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/jacs.5b05683

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
Defence Science and Technology Laboratory More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of the American Chemical Society Journal website
Volume:
137
Issue:
29
Pages:
9242-9245
Publication date:
2015-07-20
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Source identifiers:
535136
Language:
English
Pubs id:
pubs:535136
UUID:
uuid:cdf45448-96fd-4dcb-948d-fa4e1da0e84d
Local pid:
pubs:535136
Deposit date:
2016-03-01

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