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Journal article

In vivo transfer of GPI-linked complement restriction factors from erythrocytes to the endothelium.

Abstract:

Many proteins are associated with the outer layer of the cell membrane through a posttranslationally added glycosyl phosphatidylinositol (GPI) anchor. The functional significance of this type of protein linkage is unclear, although it results in increased lateral mobility, sorting to the apical surface of the cell, reinsertion into cell membranes, and possibly cell signaling. Here evidence is presented that GPI-linked proteins can undergo intermembrane transfer in vivo. GPI-linked proteins ex...

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Publication status:
Published

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Publisher copy:
10.1126/science.7541557

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Journal:
Science (New York, N.Y.) More from this journal
Volume:
269
Issue:
5220
Pages:
89-92
Publication date:
1995-07-01
DOI:
EISSN:
1095-9203
ISSN:
0036-8075

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