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Prognostic value, localization and correlation of PD-1/PD-L1, CD8 and FOXP3 with the desmoplastic stroma in pancreatic ductal adenocarcinoma.

Abstract:

We examined the prognostic value of programmed cell death-1 (PD-1) and its ligand (PD-L1) together with CD8+ tumor-infiltrating lymphocytes (TILs) and FOXP3+ Tregs in resectable pancreatic ductal adenocarcinoma (PDAC) samples treated with adjuvant chemotherapy. Whole-mount FFPE tissue sections from 145 pancreatectomies were immunohistochemically stained for PD-1, PD-L1, CD8 and FOXP3. Their expression was correlated with clinicopathological characteristics, and overall survival (OS), progress...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.18632/oncotarget.10038

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
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Cancer Research UK More from this funder
Marie Curie Innovative Training Network More from this funder
Kidani Memorial Trust More from this funder
Publisher:
Impact Journals Publisher's website
Journal:
Oncotarget Journal website
Publication date:
2016-06-14
Acceptance date:
2016-05-14
DOI:
EISSN:
1949-2553
Source identifiers:
631017
Language:
English
Keywords:
Pubs id:
pubs:631017
UUID:
uuid:cde9a669-db83-4b09-b31e-b58bee5395b8
Local pid:
pubs:631017
Deposit date:
2016-07-05

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