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Senktide, a selective neurokinin B-like agonist, elicits serotonin-mediated behaviour following intracisternal administration in the mouse.

Abstract:

Behavioural responses to tachykinins were observed following intracisternal administration in mice. The synthetic NK-3 agonists senktide and L-363,851 caused behaviour typically associated with serotonergic stimulation, including head twitches, reciprocal forepaw treading and hindlimb splaying. Neurokinin B produced some features of the serotonin (5-HT) syndrome, while substance P, neurokinin A and eledoisin failed to elicit any such behaviours. Senktide-induced head twitches were prevented b...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
Journal:
Neuroscience letters More from this journal
Volume:
80
Issue:
3
Pages:
321-326
Publication date:
1987-10-01
DOI:
EISSN:
1872-7972
ISSN:
0304-3940
Language:
English
Keywords:
Pubs id:
pubs:6843
UUID:
uuid:cde4fce9-9798-42a2-a973-54a4d87f02c4
Local pid:
pubs:6843
Source identifiers:
6843
Deposit date:
2012-12-19

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