Journal article
A dynamic folded Hairpin conformation is associated with α-Globin activation in Erythroid cells
- Abstract:
-
We investigate the three-dimensional (3D) conformations of the α-globin locus at the single-allele level in murine embryonic stem cells (ESCs) and erythroid cells, combining polymer physics models and high-resolution Capture-C data. Model predictions are validated against independent fluorescence in situ hybridization (FISH) data measuring pairwise distances, and Tri-C data identifying three-way contacts. The architecture is rearranged during the transition from ESCs to erythroid cells, assoc...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Elsevier (Cell Press) Publisher's website
- Journal:
- Cell Reports Journal website
- Volume:
- 30
- Issue:
- 7
- Pages:
- 2125-2135.e5
- Publication date:
- 2020-02-18
- Acceptance date:
- 2020-01-14
- DOI:
- EISSN:
-
2211-1247
- ISSN:
-
2211-1247
- Pmid:
-
32075757
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1089195
- Local pid:
- pubs:1089195
- Deposit date:
- 2020-03-09
Terms of use
- Copyright holder:
- Chiariello et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 The Authors.. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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