- Abstract:
-
The scientific community has avoided using tissue samples from patients that have been exposed to systemic chemotherapy to infer the genomic landscape of a given cancer. Esophageal adenocarcinoma is a heterogeneous, chemoresistant tumor for which the availability and size of pretreatment endoscopic samples are limiting. This study compares whole-genome sequencing data obtained from chemo-naive and chemo-treated samples. The quality of whole-genomic sequencing data is comparable across all sam...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.5mb)
-
- Publisher copy:
- 10.1101/gr.214296.116
-
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- Institution:
- University of Oxford
- Division:
- MPLS Division
- Department:
- Computer Science
- Oxford college:
- Kellogg College
- Role:
- Contributor
- Publisher:
- Cold Spring Harbor Laboratory Press Publisher's website
- Journal:
- Genome Research Journal website
- Volume:
- 27
- Issue:
- 6
- Pages:
- 902-912
- Publication date:
- 2017-05-02
- Acceptance date:
- 2017-04-06
- DOI:
- EISSN:
-
1549-5469
- ISSN:
-
1088-9051
- Pubs id:
-
pubs:692314
- URN:
-
uri:cddad6a5-fa7f-4adb-a937-b8b7c1292786
- UUID:
-
uuid:cddad6a5-fa7f-4adb-a937-b8b7c1292786
- Local pid:
- pubs:692314
- Language:
- English
- Copyright holder:
- Noorani et al.
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 Noorani et al.; Published by Cold Spring Harbor Laboratory Press
This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.
Journal article
A comparative analysis of whole genome sequencing of esophageal adenocarcinoma pre- and post-chemotherapy
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Authors
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+ Davies, J
Funding
Biomedical Research Centre and the Experimental Cancer Medicine Centre
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