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A comparative analysis of whole genome sequencing of esophageal adenocarcinoma pre- and post-chemotherapy

Abstract:

The scientific community has avoided using tissue samples from patients that have been exposed to systemic chemotherapy to infer the genomic landscape of a given cancer. Esophageal adenocarcinoma is a heterogeneous, chemoresistant tumor for which the availability and size of pretreatment endoscopic samples are limiting. This study compares whole-genome sequencing data obtained from chemo-naive and chemo-treated samples. The quality of whole-genomic sequencing data is comparable across all sam...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.1101/gr.214296.116

Authors


Noorani, A More by this author
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ORCID:
0000-0001-8673-3122
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ORCID:
0000-0002-7876-7338
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ORCID:
0000-0003-2758-1741
Achilleos, A More by this author
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Contributors

Institution:
University of Oxford
Division:
MPLS Division
Department:
Computer Science
Oxford college:
Kellogg College
Role:
Contributor
Biomedical Research Centre and the Experimental Cancer Medicine Centre More from this funder
Publisher:
Cold Spring Harbor Laboratory Press Publisher's website
Journal:
Genome Research Journal website
Volume:
27
Issue:
6
Pages:
902-912
Publication date:
2017-05-02
Acceptance date:
2017-04-06
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
Pubs id:
pubs:692314
URN:
uri:cddad6a5-fa7f-4adb-a937-b8b7c1292786
UUID:
uuid:cddad6a5-fa7f-4adb-a937-b8b7c1292786
Local pid:
pubs:692314
Language:
English

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