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Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virus.

Abstract:

Immune escape mutations that revert back to the consensus sequence frequently occur in newly HIV-1-infected individuals and have been thought to render the viruses more fit. However, their impact on viral fitness and their interaction with other immune escape mutations have not been evaluated in the background of their cognate transmitted/founder (T/F) viral genomes. To precisely determine the role of reversion mutations, we introduced reversion mutations alone or together with CD8+ T cell es...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0102734

Authors


Bhattacharya, T More by this author
Goonetilleke, N More by this author
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Publisher:
Public Library of Science
Journal:
PloS one
Volume:
9
Issue:
7
Pages:
e102734
Publication date:
2014
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:cdd9e534-fe8d-4341-8e82-764dde8356fe
Source identifiers:
476253
Local pid:
pubs:476253
Language:
English

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