Journal article
Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virus.
- Abstract:
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Immune escape mutations that revert back to the consensus sequence frequently occur in newly HIV-1-infected individuals and have been thought to render the viruses more fit. However, their impact on viral fitness and their interaction with other immune escape mutations have not been evaluated in the background of their cognate transmitted/founder (T/F) viral genomes. To precisely determine the role of reversion mutations, we introduced reversion mutations alone or together with CD8+ T cell es...
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- Publication status:
- Published
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(pdf, 897.8KB)
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- Publisher copy:
- 10.1371/journal.pone.0102734
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Authors
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PloS one
- Volume:
- 9
- Issue:
- 7
- Pages:
- e102734
- Publication date:
- 2014-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
- URN:
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uuid:cdd9e534-fe8d-4341-8e82-764dde8356fe
- Source identifiers:
-
476253
- Local pid:
- pubs:476253
Item Description
- Language:
- English
Terms of use
- Copyright date:
- 2014
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