Journal article
A synthetic peptide designed to neutralize lipopolysaccharides attenuates metaflammation and diet-induced metabolic derangements in mice
- Abstract:
-
Metabolic endotoxemia has been suggested to play a role in the pathophysiology of metaflammation, insulin-resistance and ultimately type-2 diabetes mellitus (T2DM). The role of endogenous antimicrobial peptides (AMPs), such as the cathelicidin LL-37, in T2DM is unknown. We report here for the first time that patients with T2DM compared to healthy volunteers have elevated plasma levels of LL-37. In a reverse-translational approach, we have investigated the effects of the AMP, peptide 19-2.5, i...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Telethon
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Bibliographic Details
- Publisher:
- Frontiers Media Publisher's website
- Journal:
- Frontiers in Immunology Journal website
- Volume:
- 12
- Article number:
- 701275
- Publication date:
- 2021-07-19
- Acceptance date:
- 2021-06-29
- DOI:
- EISSN:
-
1664-3224
- Pmid:
-
34349763
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1190397
- Local pid:
- pubs:1190397
- Deposit date:
- 2022-01-14
Terms of use
- Copyright holder:
- Mohammad et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 Mohammad, Al Zoubi, Collotta, Krieg, Wissuwa, Ferreira Alves, Purvis, Norata, Baragetti, Catapano, Solito, Zechendorf, Schürholz, Correa-Vargas, Brandenburg, Coldewey, Collino, Yaqoob, Martin and Thiemermann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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