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Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases

Abstract:

Ferrous iron and 2-oxoglutarate-dependent oxygenases and related enzymes catalyse a range of oxidative reactions, possibly the widest of any enzyme family. Their catalytic flexibility is proposed to be related to their nonhaem iron-binding site, which utilizes two or three protein-based ligands. A possible penalty for this flexibility is that they may be more prone to oxidative damage than the P450 oxidases, where the iron is arguably located in a more controlled environment. We review the ev...

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Authors


McDonough, MA More by this author
Schofield, CJ More by this author
Journal:
FEBS Journal
Volume:
279
Issue:
9
Pages:
1563-1575
Publication date:
2012-05-05
DOI:
EISSN:
1742-4658
ISSN:
1742-464X
URN:
uuid:cdd8f592-7f58-4177-b0e8-7a0aa00369ec
Source identifiers:
341445
Local pid:
pubs:341445

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