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6-methyl delta-lactol derived chiral glycine equivalents for the asymmetric synthesis of protected alpha-amino amides

Abstract:
Two new δ-lactol derived chiral glycine equivalents have been prepared in one-pot processes in good yields from the known 6- methyltetrahydropyran-2-ol. Alkylation proceeds in moderate to good yields and moderate to good selectivities under experimentally simple conditions. The lactol chiral auxiliary is readily removed under mild acidic conditions to give N-Cbz protected alpha-amino amides in good yields. © 2004 Elsevier Ltd. All rights reserved.
Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
TETRAHEDRON-ASYMMETRY More from this journal
Volume:
15
Issue:
6
Pages:
913-916
Publication date:
2004-03-22
DOI:
ISSN:
0957-4166
Language:
English
Pubs id:
pubs:52076
UUID:
uuid:cdd6d394-6647-40be-9da7-19eba905f134
Local pid:
pubs:52076
Source identifiers:
52076
Deposit date:
2012-12-19

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