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UMOD-ulating CKD risk: untangling the relationship between urinary uromodulin, blood pressure, and kidney disease

Abstract:

A new Mendelian randomization study finds evidence that genetically predicted higher levels of urinary uromodulin are associated with lower kidney function and higher blood pressure. Bidirectional and multivariable Mendelian randomization suggests the association with higher blood pressure appears to be partially through decreased kidney function, but blood pressure does not appear to mediate the association of uromodulin with low kidney function. We describe the methods used for the bidirect...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.kint.2021.09.019

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
NPEU
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Kidney International Journal website
Volume:
100
Issue:
6
Pages:
1168-1170
Publication date:
2021-11-18
Acceptance date:
2021-09-24
DOI:
EISSN:
1523-1755
ISSN:
0085-2538
Language:
English
Keywords:
Pubs id:
1210448
Local pid:
pubs:1210448
Deposit date:
2021-11-18

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