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The measles virus receptor SLAMF1 can mediate particle endocytosis

Abstract:

The signalling lymphocyte activation molecule F1 (SLAMF1) is both a microbial sensor and entry receptor for Measles virus (MeV). Herein, we describe a new role for SLAMF1 to mediate MeV endocytosis that is in contrast with the alternative, and generally accepted, model that MeV genome enters cells only after fusion at the cell surface. We demonstrated that MeV engagement of SLAMF1 induces dramatic but transient morphological changes, most prominently in the formation of membrane blebs, which ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/JVI.02255-16

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM
Role:
Author
Medical Research Council More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Virology Journal website
Volume:
91
Issue:
7
Pages:
e02255-16
Publication date:
2017-01-01
Acceptance date:
2017-01-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Pubs id:
pubs:675248
URN:
uri:cdd1a6e0-7cc1-43c2-9574-0687a33335a9
UUID:
uuid:cdd1a6e0-7cc1-43c2-9574-0687a33335a9
Local pid:
pubs:675248
Paper number:
7
Language:
English
Keywords:

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