Journal article icon

Journal article

IL-2/B7.1 (CD80) fusagene transduction of AML blasts by a self-inactivating lentiviral vector stimulates T cell responses in vitro: a strategy to generate whole cell vaccines for AML.

Abstract:

Combined expression of costimulatory factors and proinflammatory cytokines stimulate effective immune-mediated tumor rejection in a variety of murine tumor models. Specifically, syngeneic tumor cells genetically modified to express B7.1 (CD80) have been shown to induce rejection of previously established murine solid tumors, and transduction with IL-2 can further increase survival. However, poor rates of gene transfer and inefficient expression of multiple transgenes encoded by single vectors...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.ymthe.2004.09.006

Authors


Hardwick, N More by this author
Darling, D More by this author
Galea-Lauri, J More by this author
Expand authors...
Journal:
Molecular therapy : the journal of the American Society of Gene Therapy
Volume:
11
Issue:
1
Pages:
120-131
Publication date:
2005-01-05
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
URN:
uuid:cdd06fb2-ba71-49e1-8a41-2ba643c1cd29
Source identifiers:
466386
Local pid:
pubs:466386

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP