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A site-directed spin labelling study of the human alpha-lactalbumin molten globule

Abstract:

The human α-lactalbumin (α-LA) molten globule formed at low pH is a model for the study of protein folding intermediates. The molten globule lacks native-like side-chain interactions, resulting in a fluctuating ensemble of tertiary structures, characterisation of which has been precluded by severe line-broadening in NMR spectra and a lack of long-range NOEs. Paramagnetic relaxation enhancements (PREs) have been measured in a variant of α-LA in which all native cysteines have been mutated t...

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Institution:
University of Oxford
Oxford college:
Oriel College
Department:
Medical Sciences Division - Biochemistry

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Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:cdc9904d-77cc-4d20-b01d-096bc2b16d72
Local pid:
ora:10360

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