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Effect of cessation of short-term therapy with ipratropium bromide on lung function and airway responsiveness.

Abstract:

Regular exposure to antimuscarinic drugs would be expected to upregulate airway muscarinic receptors and could cause a transient increase in airways obstruction if treatment was stopped or omitted. We have examined peak expiratory flow rate (PEFR) during treatment and forced expiratory flow in one second (FEV1) and airway responsiveness to three constrictor agonists (as the provocative dose of agonist causing a 20% fall in FEV1, (PD20)) following cessation of regular inhaled ipratropium bromi...

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Journal:
European respiratory journal
Volume:
9
Issue:
8
Pages:
1627-1631
Publication date:
1996-08-01
DOI:
EISSN:
1399-3003
ISSN:
0903-1936
Source identifiers:
435393

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