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A phase I/II study of irinotecan when added to 5-fluorouracil and leucovorin and pelvic radiation in locally advanced rectal cancer: a Colorectal Clinical Oncology Group Study.

Abstract:

The objective of this study was to evaluate the maximum tolerated dose (MTD) and recommended dose of irinotecan administered as a 5-day schedule synchronously with 5-fluorouracil (5FU), leucovorin (LV) and preoperative pelvic radiation (45 Gy) for primary borderline/unresectable, locally advanced rectal cancer. The study used escalating doses of intravenous irinotecan (6, 8, 10, 12, 14, 16, 18, and 20 mg m(-2)) administered on days 1-5 and 29-33 followed by low dose LV (20 mg m(-2)) and 5FU (...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6603570

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
British journal of cancer More from this journal
Volume:
96
Issue:
4
Pages:
551-558
Publication date:
2007-02-01
DOI:
EISSN:
1532-1827
ISSN:
0007-0920

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